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Liu Lab@NJAU
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Academic Report
Dr. Liu Jinxin explained three research stories: "The mechanism of the influence of dietary types on the gut microbiota resistance group of calves", "The impact of medication on the gut microbiota resistance group of cows and its environmental transfer", and "The structure of milk resistance groups and key factors affecting microbial resistance".
Through the lecture, the students gained a preliminary understanding of resistance genes, microbial resistance groups, the influence of feed types on the structure of calf gut resistance groups, the significant enrichment of corresponding resistance genes and resistant bacteria in calf medication, and the effective transmission of corresponding enriched bacteria in soil back to calves, which broadened their knowledge.
We chose Agaricus bisporus as a model vegetable to examine such migration and characterized the resistome in 112 metagenomes covering samples from raw manure. A total of 1864 resistance genes, representing 113 unique mechanisms of resistance, were identified. Interestingly, we found that resistance genes were significantly more enriched on mushroom surfaces when cultivated with corn-based compost compared to rice and wheat.
Importantly, our sequence alignment together with genome-centric analysis observed that 89 resistance genes, mainly conferring resistance to drug and biocide (20.22%) and mercury (19.10%), were shared across all types of samples. Moreover, co-occurrence of genes conferring resistance to different compounds frequently occurred in parallel with microbial migration. Together, we present the influences of antibiotic treatment and straw-based composting on resistome along the mushroom production chain (from manure to straw-based compost, rhizo sphere of compost cultivated mushroom and surface of mushroom) and highlighted the risks of resistance genesmigration.
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